Does anybody knows something about syntaxin 3 being cleaved? I heard that it gets cleaved and the N-terminal fragment binds to RanBP5 which mediates the targeting to the nucleus. Is that true?
I heard this from my supervisor that there is group working on this. It is pretty amazing that a molecule involved in vesicle fusion can act as signaling molecule. But I don't know much about this. But I think he also mentioned the RanBP5. So far I know there is only a cleavage site in syntaxin 3 which is missing in the other syntaxins. I searched for this information and I found something that syntaxin 3 is involved in polarizing. Maybe this cleavage product is involved in this as a signaling molecule.
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