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| ilikeick |
 Posted: Sat May 24, 2008 1:03 pm Post subject: Allegeries |
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Joined: 25 Jan 2008
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| Ok this may sound stupid but i was wondering if your are allergic to something and exposed to enough of it would you no longer by allergic. I mean to my understanding if you have enough of something (ie herbs) you are grown a allergy to them. If i am wrong correct me. But is it possible vica versa? Thanks for your help |
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| Robbie |
| Posted: Sat May 24, 2008 2:05 pm Post subject: |
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No I dont think so, there may be a maximum response whereby it would not get worse but that would have nothing to do with curing you.
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| i_feel_tiredsleepy |
| Posted: Sat May 24, 2008 4:55 pm Post subject: |
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| 425 Chaotic Requisition |
| Posted: Mon May 26, 2008 12:33 pm Post subject: |
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The Doctor
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None, that I know of.
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| Demons are real, ask God |
| Posted: Wed May 28, 2008 4:03 pm Post subject: |
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Aren't there theories that suggest that exposure to dust mites, pollen, venom and such like at a young age can prevent allergies fro developing in later life?
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| Tenacity |
| Posted: Wed May 28, 2008 5:07 pm Post subject: |
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| Yes it's to do with the developing immune system. |
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| Hanuka |
| Posted: Thu May 29, 2008 10:19 am Post subject: |
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I have a minor allergy to dust...
If I'll sniff so and so dust will I eventually be immune to it??
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| Robbie |
| Posted: Thu May 29, 2008 10:38 am Post subject: |
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No, and just to point out, many people who develop rhinorrhoea as a response to dust are not actually immune, its a reflex to the drying effect of the dust, its actually protective
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| i_feel_tiredsleepy |
| Posted: Thu May 29, 2008 10:56 am Post subject: |
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| Demons are real, ask God wrote: |
| Aren't there theories that suggest that exposure to dust mites, pollen, venom and such like at a young age can prevent allergies fro developing in later life? |
This is the hygiene hypothesis, which is supported by epidemiological studies but lacks a proper immunological explination. Dust mite allergens and cockroach feces have been found to increase rates of allergy development later in life, cat dander and the presense of dogs has correlated with decreased allergies. Moreover, living in a rural environment and having older siblings also correlates with lower incidence of allergies. Some have argued though that it is actually the higher rates of obesity and pollution in urban areas that causes more allergies rather than a high allergen area like a farm being protective against allergies.
Likewise, a couple years ago in Guinea they vaccinated children with mycobacterium and saw a decrease in allergies, which has lead to a lot of study into the effect of our bacterial flora on the development of our immune system since they play a large part in producing tolerance in the mucosal areas.
| Hanuka wrote: |
I have a minor allergy to dust...
If I'll sniff so and so dust will I eventually be immune to it?? |
No, studies have shown that dust mites proteins are one of the most allergenic compounds we have identified, they seem to elicit a very high IgE response.
The theory behind the use of an allergen to treat an allergy is based on the concept that maybe exposure in small amounts is not sufficient to produce IgG memory cells, but triggers proliferation of IgE B cells in specific mucousal tissues. If you could induce formation of enough IgG and IgA B cells then they could neutralize the allergen before it encountered the allergic response effectors that are the IgE bound eosinophils.
Last edited by i_feel_tiredsleepy on Fri May 30, 2008 10:17 am; edited 1 time in total |
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| Hanuka |
| Posted: Fri May 30, 2008 8:41 am Post subject: |
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You lost me at the first IgE... 
I dunno such terms man... plz use complete words so I can at least guess what it means 
But from what I've got from ya u say that with proper doses of dust I can become immune to it? or no?...
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| i_feel_tiredsleepy |
| Posted: Fri May 30, 2008 10:32 am Post subject: |
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OK I'll start with some basic immunology, there are two types of immune responses, humoural and cellular, cellular is the type of response where a white blood cell actively kills an intruding pathogen, the humoural response is composed of substances released by white blood cells that float around your body and combat the invasion.
The humoural aspect is what is responsible for the allergic response, the mediators of the allergic response are the IgE antibodies (IgE means immunoglobulin E). There are white blood cells in your mucousal layers like the sinus called eosinophils, they have IgE bound to them and when that IgE recognizes something the eosinophils trigger the allergic response. So you have to have specific IgE against the allergen to be allergic to it.
Now the antibodies are made by a white blood cell called a B cell, when a B cell recognizes an allergen it starts to multiply and then it has to decide what kind of antibody producing cell it is going to be. The most abundant type of antibody is IgG that is found ubiquitous in the body, and it mediates the destruction of pathogens by other white blood cells among other more complicated things. IgE is meant to mediate against parasites, and to mediate the mechanical expulsion of pathogens and is usually found in much lower levels than IgG.
For some poorly understood reason highly allergenic substances like dust mites produce a more powerful IgE response (It seems to have to do with Toll like receptors and the cytokine milieu but I would have to get into complicated biochemisty and biology to start explaining this), so exposing yourself to more dust mites would just increase the amount of IgE you produce, thus making you more likely to have an allergic response.
Now there are other theories like the case with bee venom, where the theory runs that the dosage is too small to induce the formation of IgG memory cells, so if you increased the dosage you could cause a heavier IgG response. The IgG could then just prevent the allergen from comming into contact with the IgE and prevent the allergic response. This seems to work somewhat.
Now I hope this made sense >.> |
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| Selene |
| Posted: Fri May 30, 2008 6:08 pm Post subject: |
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I seem to have an allergy to alcohol
Whenever I drink it i always seem to find myself on some kind of ship in very stormy weather and with very bad sea legs and a terrible churning in my stomach.
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| Cparkinson |
| Posted: Tue Jun 24, 2008 11:11 am Post subject: Allergy help |
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Joined: 18 Jun 2008
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| i_feel_tiredsleepy wrote: |
OK I'll start with some basic immunology, there are two types of immune responses, humoural and cellular, cellular is the type of response where a white blood cell actively kills an intruding pathogen, the humoural response is composed of substances released by white blood cells that float around your body and combat the invasion.
The humoural aspect is what is responsible for the allergic response, the mediators of the allergic response are the IgE antibodies (IgE means immunoglobulin E). There are white blood cells in your mucousal layers like the sinus called eosinophils, they have IgE bound to them and when that IgE recognizes something the eosinophils trigger the allergic response. So you have to have specific IgE against the allergen to be allergic to it.
Now the antibodies are made by a white blood cell called a B cell, when a B cell recognizes an allergen it starts to multiply and then it has to decide what kind of antibody producing cell it is going to be. The most abundant type of antibody is IgG that is found ubiquitous in the body, and it mediates the destruction of pathogens by other white blood cells among other more complicated things. IgE is meant to mediate against parasites, and to mediate the mechanical expulsion of pathogens and is usually found in much lower levels than IgG.
For some poorly understood reason highly allergenic substances like dust mites produce a more powerful IgE response (It seems to have to do with Toll like receptors and the cytokine milieu but I would have to get into complicated biochemisty and biology to start explaining this), so exposing yourself to more dust mites would just increase the amount of IgE you produce, thus making you more likely to have an allergic response.
Now there are other theories like the case with bee venom, where the theory runs that the dosage is too small to induce the formation of IgG memory cells, so if you increased the dosage you could cause a heavier IgG response. The IgG could then just prevent the allergen from comming into contact with the IgE and prevent the allergic response. This seems to work somewhat.
Now I hope this made sense >.> |
hello everyone,
Thank you so much for this information, it helps me understand allergies much better. As for the bee venom, I have heard that if you take bee pollen as a supplement you can help build a natural allergy resistance. I think it works for many outdoor allergens, and bee pollen contains many beneficial nutrients as well.
http://www.womens-health-fitness.com/bee-pollen-benefits.html
and...
http://www.alternativescentral.com/beepollen.htm
blue cross blue shield of north carolina |
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| Michell3z |
| Posted: Tue Aug 26, 2008 2:09 am Post subject: |
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